Return of Reckoning

Returning player here, have forgotten everything was wondering how I would normally open on a gank is all! Right now I try to do envenomed x3, witchbrew on 5 stacks, and then the ability that lets you ignore the flanking requirement on agonizing wounds, but I'm sure that's not optimal!

Is there a general consensus on what the best weapons are for a defensive WE build? I know the scenario weapons have regen on them, but most run the bb/be influence weapons from the people I've talked to in game.